Tag Archives: AKAO

Rounds Report: Achaogen And Eleven To Clear Their Binaries For Substantial Gains

Were emphasizing the knowable by predicting how certain people and companies will swim against the current. Were not predicting the fluctuation in the current. – Charlie Munger

Trading Analytics

Welcome to this edition of Integrated BioSci Rounds Report for April 27, 2018. As usual, well elucidate notable trading analytics for the day, recent insider transactions, and interesting market developments. Without further ado, lets take an overall assessment of the bioscience space. As follows, the iShares of NASDAQ Biotechnology Index (NASDAQ:IBB) traded up $0.31 (+0.29%) at $105.61. Moreover, the SPDR S&P Biotech (NYSE:XBI) exchanged hands $0.58 higher at $88.42 (for +0.66% gains). Its likely that investors were trading with a more positive sentiment for the day. Regardless of the daily inclination, there are substantial prospects in the bioscience sector: one that delivers hope for patients while rewarding supporters with substantial wealth in the long haul.

Figure 1: Notable BioSci movers. (Source: Morningstar)

Moving to specific equities, Eleven Biotherapeutics (NASDAQ:EBIO) – a company focusing on the innovation and commercialization of the novel molecules, Targeted Protein Therapeutics (TPTs) – won the highlight for the day. Following a strong momentum this week, the shares exchanged hands $0.16 higher to close the session at $2.51 (for over 6.8% profits). In addition, the stock added over 31% and 130% for the past week and previous month, respectively.

Of note, TPT is a fusion drug (an antibody linked a cytotoxic protein payload that, in and of itself, is designed for the localized cancer destruction). The said antibody zones in on specific cancer cells while the cytotoxic protein kills rogue tumors. Interestingly, TPT can be employed as either a promising single drug or in combinations with other immuno-oncology agents such as checkpoint inhibitors.

Interestingly, Eleven commenced a trial at the US National Cancer Institute (NCI) back on Sept. 2017 to study the prospects of Vicinium – a protein coupled with an antibody to attack EpCAM positive tumor – in combinations with AstraZeneca (NYSE:AZN)s immune checkpoint inhibitor, Imfinzi for high-grade non-muscle invasive bladder cancer (NMIBC). If the data turns out robust as we anticipated, AstraZeneca is likely to acquire the company. That aside, the VISTA trial investigating Vicinium as a monotherapy for NMIBC will report the topline results in several months. There is a favorable chance that this clinical binary to post positive outcomes to catapult the shares over 80%. Be that as it may, there is a risk that the shares can tumble by similar the magnitude.

Bioscience Catalysts

On April 26, 2018, Achaogen (NASDAQ:AKAO) announced that it has entered into an award agreement with CARB-X. Under the terms, Achaogen to receive the initial $2.4M (and potentially $9.6M more, pending on certain milestones achievement). As a company featured in our Specialty Report, Achaogen seeks to develop and commercialize the next-generation antibiotics (to service multi-drug resistant gram-negative infection).

Notably, the aforementioned collaboration to assist the company in innovating a next-generation broad-spectrum aminoglycoside that can circumvent the highly resistant gram-negative bugs such as Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. It is interesting to realize that in 2017, the World Health Organization recognized multi-drug resistant P. aeruginosa, A. baumannii and various Enterobacteriaceae as priority 1 critical pathogens that pose the greatest threat to human health.

Final Remarks

In all, the market finished the week on a positive tune. Notable companies either rode this rays of optimism or made our featured list today include Eleven Biotherapeutics and Achaogen. Its highly likely that Eleven bulls will continue to charge ahead of the clinical binary for Vicinium. That aside, the recent CARB-X award is a testament to the quality of Achaogen antibiotics.

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